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Serum level of the circulating angiogenesis inhibitor endostatin in patients with hyperthyroidism or hypothyroidism
Eugene J Kucharz1, Anna Kotulska, Magdalena Kopeć
1Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland. ekucharz@slam.katowice.pl
Abstract:
Serum level of endostatin, a natural angiogenesis inhibitor, was measured in 12 patients with hyperthyroidism and 9 patients with hypothyroidism. Control values were obtained from 12 healthy individuals. Hyperthyroidism was shown to be associated with an increased level of endostatin and hypothyroidism with a decreased endostatin level. There was no correlation of serum endostatin with thyroid hormone levels. Endostatin is a fragment of type XVIII collagen, and it is possible that reported changes are related to the effect of thyroid hormones on connective tissue metabolism.
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