[Nonallergic rhinitis with eosinophilia syndrome: state of knowledge]

The aim of our article was to present the actual state of knowledge of the non-allergic rhinitis with eosinophilia syndrome (NARES). NARES is characterized by perennial rhinitis and nasal eosinophilia in the absence of allergy in patient's history, negative skin tests and normal IgE. This syndrome was described 20 years ago, but studies on it are scarce. NARES is more frequent in females at mean age. Family history is positive in part of cases. The clinical symptoms are sneezing, watery rhinorrhea, nasal obturation and nasal itching. The precipitating factors are often nonspecific irritants, weather changes or strong odors. It is not sure whether NARES is a form of a vasomotor rhinitis or a first stage of aspirin triad. A presence of bronchial hyperactivity was detected in part of patients with NARES. The crucial feature of the non-allergic rhinitis with eosinophilia syndrome is nasal eosinophilia. Its diagnosing value, mechanisms and different methods of its measurement and differential diagnosis are discussed. The treatment of NARES with nasal steroids is highly effective. The patients may also benefit from the treatment with the oral antihistamines.