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Validity of the general practice research database.

Susan S Jick1, James A Kaye, Catherine Vasilakis-Scaramozza

  • 1Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA. sjick@bu.edu

Pharmacotherapy
|May 14, 2003
PubMed
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The United Kingdom General Practice Research Database (GPRD) provides valuable data for epidemiologic research, particularly in drug safety. This review evaluates the quality and completeness of GPRD data, confirming its validity for research purposes.

Area of Science:

  • Epidemiologic Research
  • Pharmacovigilance
  • Health Informatics

Background:

  • The United Kingdom General Practice Research Database (GPRD) is a significant resource for medical research.
  • A specialized version is managed by the Boston Collaborative Drug Surveillance Program, contributing to over 130 publications.
  • These publications predominantly focus on drug safety issues.

Purpose of the Study:

  • To review and assess the evidence regarding the validity of the GPRD.
  • To evaluate the quality and completeness of the data within the GPRD.
  • To leverage extensive experience with the automated database for a thorough evaluation.

Main Methods:

  • Review of existing evidence on GPRD validity.
  • Evaluation of data quality and completeness.

Related Experiment Videos

  • Utilizing practical experience with the automated database.

    • Main Results:

    • The GPRD is a robust, office-based, computer-generated medical resource.
    • The database has been instrumental in numerous scientific articles, especially concerning drug safety.
    • Evidence reviewed supports the validity of the GPRD for research.

    Conclusions:

    • The GPRD is a valid and reliable data source for epidemiologic research.
    • The quality and completeness of GPRD data are confirmed.
    • The database serves as a crucial tool for drug safety surveillance and other research areas.