Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Donor-transmitted coronary atherosclerosis.

Onnen Grauhan1, Johannes Patzurek, Manfred Hummel

  • 1Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany. grauhan@dhzb.de

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|May 14, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paradoxical sparing of cerebral circulation in massive TAVR-associated endocarditis.

Journal of cardiothoracic surgery·2026
Same author

Assessment of Right Ventricular Adaptability to Pressure Overloading for Critical Therapeutic Decision-Making Processes.

Journal of clinical medicine·2026
Same author

Post-infarction ventricular septal defect repair: cardioplegic arrest vs. on-pump beating-heart strategy-ten years of experience.

Frontiers in cardiovascular medicine·2025
Same author

Partial Removal of Mechanical Aortic Valve to Enable Direct Transcatheter Valve Implantation During Left Ventricular Assist Device Placement.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2025
Same author

Cardiac structural and functional damage induced and/or increasingly aggravated by aortic valve stenosis.

Cardiovascular diagnosis and therapy·2025
Same author

Autoimmunity in Cardiomyopathy-Induced Heart Failure and Cardiac Autoantibody Removal by Immunoadsorption.

Journal of clinical medicine·2025

Donor hearts frequently carry significant coronary atherosclerosis, posing a risk for heart transplant recipients. Current donor screening without coronary angiography misses many cases, necessitating policy changes for improved patient outcomes.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Vascular Biology

Background:

  • Coronary atherosclerosis is common even in young, healthy individuals.
  • Previous guidelines did not mandate coronary angiography for heart donors under 60 years old.
  • The study investigates the transmission of native coronary atherosclerosis from donor to recipient.

Purpose of the Study:

  • To evaluate the extent of native coronary atherosclerosis transmission during heart transplantation.
  • To assess the impact of donor coronary atherosclerosis on transplant outcomes.

Main Methods:

  • Analysis of 1253 heart transplant cases between April 1986 and December 2000.
  • Definition of transmitted coronary atherosclerosis based on post-transplant coronary evaluation (angiogram or autopsy) within 6 months.

Related Experiment Videos

  • Exclusion of cases without timely coronary evaluation or those with pre-transplant angiography.

    • Main Results:

    • Significant coronary atherosclerosis (>=50% stenosis) was found in 7.0% of inadvertently transmitted donor hearts.
    • Prevalence of transmitted atherosclerosis was 5.2% in post-transplant angiograms and 15.1% in autopsies within 6 months.
    • Higher prevalence (22.8%) observed in early graft failure cases, indicating a link to donor atherosclerosis.

    Conclusions:

    • The donor pool has a high prevalence of coronary atherosclerosis, often undetected by current screening.
    • Donor-transmitted coronary atherosclerosis is a significant risk factor for short-term survival and early graft failure.
    • Policy has been updated to include coronary angiography for donors aged 40 and older.