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Influence of vitamin C on baroreflex sensitivity in chronic heart failure
Gianfranco Piccirillo1, Marialuce Nocco, Antonio Moisè
1Dipartimento di Scienze dell'Invecchiamento, I Clinica Medica, Policlinico Umberto I, Università La Sapienza, 00161 Rome, Italy. gianfranco.piccirillo@uniroma1.it
Hypertension (Dallas, Tex. : 1979)
|May 14, 2003
Abstract:
Chronic heart failure (CHF) reduces baroreflex sensitivity. Low baroreflex sensitivity, a risk factor for sudden death, could arise partly from CHF-dependent endothelial dysfunction. Vitamin C at high doses has a protective role against CHF-related endothelial damage. This study was conducted to investigate the effect of vitamin C on baroreflex sensitivity in CHF. A study group of 33 subjects with CHF secondary to postischemic dilated cardiomyopathy with an ejection fraction