Related Experiment Video
Updated: Aug 4, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
(+/-)-5-(4-methoxyphenylaminocarbonyl)-1-azabicyclo[3.3.0]octan-2-one benzene solvate
1Department of Chemistry, Delaware State University, Dover, DE 19901, USA. kwheeler@dsc.edu
Abstract:
The title trans prolyl amide exists as a benzene solvate, C(15)H(18)N(2)O(3).C(6)H(6), with positional disorder of the prolyl ring. The molecular structure is influenced by a close intramolecular N-H...N contact that provides structural support for the intramolecular catalysis of peptidyl-prolyl cis-trans isomerization.
Related Concept Videos
01:12Solvents
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
A...
02:34Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
02:26Preparation and Reactions of Sulfides
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
01:33Carboxylic Acids to Methylesters: Alkylation using Diazomethane
Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.