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CD31 staining in epithelioid sarcoma.

M A den Bakker1, S J Flood, M Kliffen

  • 1Department of Pathology, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, Netherlands. m.denbakker@erasmusmc.nl

Virchows Archiv : an International Journal of Pathology
|May 14, 2003
PubMed
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Epithelioid sarcoma in a finger showed unusual CD31 staining. While not proving endothelial origin, this finding is crucial for differentiating epithelioid sarcoma from vascular tumors like angiosarcoma.

Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • Epithelioid sarcoma is a rare soft tissue sarcoma.
  • Its histological and ultrastructural features are typically diagnostic.
  • The endothelial origin of epithelioid sarcoma remains debated.

Observation:

  • A case of epithelioid sarcoma presented in a 27-year-old female's finger.
  • Standard histological and electron microscopy findings were characteristic.
  • Unusually, strong membranous CD31 staining was observed via immunohistochemistry.

Findings:

  • CD31 staining, typically a vascular marker, was positive in this epithelioid sarcoma.
  • Other vascular markers, including factor-VIII-related antigen (FVIIIrag), were negative.

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  • This contrasts with typical vascular tumors where FVIIIrag is usually positive.

    • Implications:

    • The findings suggest CD31 positivity in epithelioid sarcoma does not confirm endothelial derivation.
    • CD31 staining can be a useful marker in the differential diagnosis of epithelioid sarcoma versus vascular tumors.
    • Factor-VIII-related antigen remains a reliable antibody to rule out angiosarcoma.