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Updated: Jul 22, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[The morphological differences in tuberculous inflammation foci, which reflect the body's immunological
Abstract:
A comparative study of morphological reaction in the foci of tuberculous inflammation in decreased patients with caseous pneumonia (n = 2), fibrocavernous pulmonary tuberculosis (n = 19), disseminated tuberculosis (n = 5) and on the material of resected parts of the lung (infiltrate in a phase of separation (n = 2), tuberculomas (n = 22), caverns (n = 5)) has shown that exudative and necrotic reactions with minimum discriminating signs and no epitheliocytes, by accompanying by atrophy of the paracortical area of intrathoracic lymph nodes reflect immediate hypersensitivity. The decrease in the rate of exudative necrotic reactions, the increase in fibroplastic processes, and the appearance of epitheliocytes suggest that immediate hypersensitivity is added by delayed hypersensitivity. Pronounced fibroplastic reactions around the foci of caseosis and on the walls of tuberculous caverns, involvement of epitheliocytes in cellular reactions point to the fact that a tuberculous process develops in delayed hypersensitivity.
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