Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytogenetic and genetic studies in solid tumors: background.

John Swansbury1

  • 1Academic Haematology and Cytogenetics, The Royal Marsden NHS Trust, The Institute of Cancer Research, Surrey, UK.

Methods in Molecular Biology (Clifton, N.J.)
|May 15, 2003
PubMed
Summary

Cytogenetic and genetic studies in solid tumors offer diagnostic and prognostic insights. Identifying specific genetic abnormalities can guide treatment and distinguish malignancy from reactive conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clonal diversity of MYC amplification evaluated by fluorescent in situ hybridisation and digital droplet polymerase chain reaction in oesophagogastric cancer: Results from a prospective clinical trial screening programme.

European journal of cancer (Oxford, England : 1990)·2019
Same author

Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques.

Virchows Archiv : an international journal of pathology·2017
Same author

The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities.

British journal of cancer·2017
Same author

Recurrent Cytogenetic Abnormalities in Myeloproliferative Neoplasms and Chronic Myeloid Leukemia.

Methods in molecular biology (Clifton, N.J.)·2016
Same author

The distinctive micromegakaryocytes of transformed chronic myeloid leukemia.

American journal of hematology·2016
Same author

Ancillary molecular analysis in the diagnosis of soft tissue tumours: reassessment of its utility at a specialist centre.

Journal of clinical pathology·2015

Area of Science:

  • Oncology
  • Genetics
  • Cytogenetics

Background:

  • Cytogenetic and genetic studies of solid tumors are rapidly advancing.
  • These studies offer research opportunities and potential patient benefits.
  • Genetic abnormalities in tumors can aid diagnosis and predict treatment response, similar to findings in leukemias.

Purpose of the Study:

  • To explore the diagnostic and prognostic value of cytogenetic and genetic abnormalities in solid tumors.
  • To differentiate malignant conditions from reactive cellular changes using genetic markers.
  • To investigate the significance of common abnormalities like chromosome 1 rearrangements and trisomy 7 in tumor tissues and surrounding environments.

Main Methods:

  • Analysis of cytogenetic and genetic data from solid tumor samples.

Related Experiment Videos

  • Correlation of specific chromosomal abnormalities with clinical features and diagnoses.
  • Examination of ubiquitous abnormalities (e.g., chromosome 1 rearrangements) and specific events (e.g., trisomy 7).

    • Main Results:

    • Certain genetic abnormalities can establish a definitive diagnosis and predict treatment response in solid tumors.
    • Ubiquitous chromosome abnormalities, such as chromosome 1 rearrangements, help distinguish malignancy from reactive conditions.
    • Trisomy 7 is frequently observed in various tumors and surrounding tissues, with its exact significance requiring further elucidation.

    Conclusions:

    • Cytogenetic and genetic studies are crucial for diagnosing and managing solid tumors.
    • Specific genetic markers hold significant potential for personalized cancer treatment.
    • Further research is needed to clarify the role of abnormalities like trisomy 7 in tumor development and the tumor microenvironment.