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Synthesis and biological activities of 2-functionalized purine nucleosides
Vasu Nair1, Bindu Bera, Earl R Kern
1Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA. vnair@rx.uga.edu
Nucleosides, Nucleotides & Nucleic Acids
|May 15, 2003
Abstract:
Novel purine nucleosides functionalized at the 2-position have been prepared using new applications of synthetic methodology. The target molecules were designed as potential inhibitors (as their monophosphates) of the enzyme, inosine monophosphate dehydrogenase (IMPDH), and representative inhibition data are presented. Antiviral data of the compounds are discussed.