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Convenient synthesis of 8-amino-2'-deoxyadenosine
Miriam Frieden1, Anna Aviñó, Ramon Eritja
1Instituto de Biologia Molecular de Barcelona, C.S.I.C. Jordi Girona, Barcelona, Spain.
Nucleosides, Nucleotides & Nucleic Acids
|May 15, 2003
Abstract:
We studied the behaviour of 8-azido-2'-deoxyadenosine and 8-bromo-2'-deoxyadenosine in aqueous solutions of ammonia and primary and secondary amines. Unexpectedly, 8-Azido-2'-deoxyadenosine is converted to 8-amino-2'-deoxyadenosine in excellent yields. The use of this reaction for the preparation of 8-aminoadenine derivatives needed for the preparation of oligonucleotides carrying 8-aminoadenine is discussed.