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Synthesis, conformation, and antiviral activity of 5-methoxymethyl-2'-deoxycytidine analogs
Wajdi M Zoghaib1, Shajan Mannala, V Sagar Gupta
1Department of Chemistry, United Arab Emirates University, Al Ain, UAE. WajdiZ@uaeu.ac.ae
Nucleosides, Nucleotides & Nucleic Acids
|May 15, 2003
Abstract:
Analogs of 5-methoxymethyl-2'-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.