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Tests of pancreatic function using 75Se-selenomethionine
Acta Hepato-Gastroenterologica
|April 1, 1976
Summary
This study shows that combining pancreatic scans with 75Se-Selenomethionine excretion tests offers a convenient way to assess exocrine function. The 105-150 minute test provides accurate pancreatic function results.
Area of Science:
- Gastroenterology
- Nuclear Medicine
- Diagnostic Imaging
Background:
- Assessing exocrine pancreatic function is crucial for diagnosing various gastrointestinal and liver diseases.
- Conventional diagnostic methods can be invasive or time-consuming.
Purpose of the Study:
- To evaluate the efficacy of combined conventional and subtraction pancreatic scans with 75Se-Selenomethionine excretion measurements for assessing pancreatic exocrine function.
- To determine the diagnostic accuracy and convenience of this combined method.
Main Methods:
- Investigated pancreatic function in 43 patients with gastrointestinal conditions and 7 controls.
- Utilized conventional and subtraction scans of the pancreas.
- Measured 75Se-Selenomethionine activity in duodenal aspirates at specific time intervals (60-150 min, 90-120 min, 105-150 min).
Main Results:
- Pancreatic scanning alone yielded an error rate of 23.3% (8 false positives, 2 false negatives).
- 75Se-Selenomethionine excretion testing between 105-150 minutes showed a lower error rate of 14% (6 false results).
- Only one patient had false positive results from both methods.
Conclusions:
- The combined approach of pancreatic scanning and 75Se-Selenomethionine excretion measurement (105-150 min) is a convenient and effective method for evaluating pancreatic exocrine function.
- This integrated approach can be completed within a single three-hour session, improving diagnostic efficiency.