Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

9.1K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
9.1K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

16.0K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
16.0K
Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

12.3K
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
12.3K
Two-Dimensional Microscopy in Microbiology01:29

Two-Dimensional Microscopy in Microbiology

1.8K
Two-dimensional (2D) microscopy encompasses a range of optical techniques that capture images within a single focal plane, offering detailed representations of microscopic structures. These techniques are essential in biological and medical research, enabling the visualization of cellular and subcellular structures with different levels of contrast and specificity.There are several major types of 2D microscopy, each with strengths and applications.Bright-Field MicroscopyBright-field microscopy...
1.8K
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

907
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
907

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

German guidelines for the diagnosis and treatment of squamous-cell carcinoma and adenocarcinoma of the esophagus-version 4.0.

ESMO gastrointestinal oncology·2026
Same author

The overall metastatic rate in early esophageal adenocarcinoma: long-time follow-up of surgically treated patients.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2019
Same author

Editorial: the diminishing returns of normalisation of the oesophageal mucosa-Authors' reply.

Alimentary pharmacology & therapeutics·2017
Same author

The dynamics of the oesophageal squamous epithelium 'normalisation' process in patients with gastro-oesophageal reflux disease treated with long-term acid suppression or anti-reflux surgery.

Alimentary pharmacology & therapeutics·2017
Same author

[Safety of sedation during gastroscopy and colonoscopy in low-risk patients - results of a retrospective subgroup analysis of a registry study including over 170 000 endoscopies].

Zeitschrift fur Gastroenterologie·2016
Same author

Early-stage adenocarcinoma of the esophagus with mid to deep submucosal invasion (pT1b sm2-3): the frequency of lymph-node metastasis depends on macroscopic and histological risk patterns.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2016
Same journal

CTCF-rs705704-SUOX axis is important for the association between hypothyroidism and metabolic dysfunction-associated steatotic liver disease.

Gut·2026
Same journal

<i>Helicobacter pylori</i> infection, treatment and colorectal cancer risk by genetic predisposition: evidence from two randomised trials.

Gut·2026
Same journal

Correction: Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.

Gut·2026
Same journal

Correction: Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases.

Gut·2026
Same journal

Cancer risk in autoimmune gastritis: perspectives from a Chinese cohort.

Gut·2026
Same journal

Efficacy of gut-brain neuromodulators and brain-gut behaviour therapies for irritable bowel syndrome: systematic review and network meta-analysis.

Gut·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
13:49

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 12, 2011

36.2K

Improving endoscopic resolution and sampling: fluorescence techniques.

C Ell1

  • 1Department of Medicine II, Wiesbaden Hospital, Ludwig-Erhard-Strasse 100, 65199 Wiesbaden, Germany. dekanat@med.uni-erlangen.de

Gut
|May 15, 2003
PubMed
Summary
This summary is machine-generated.

Early diagnosis of gastrointestinal tumours is crucial for improving patient prognosis. Enhancing intraluminal diagnostic methods in gastroenterology is key to detecting these cancers at their earliest stages.

More Related Videos

Visualization of Endosome Dynamics in Living Nerve Terminals with Four-dimensional Fluorescence Imaging
10:51

Visualization of Endosome Dynamics in Living Nerve Terminals with Four-dimensional Fluorescence Imaging

Published on: April 16, 2014

8.5K
Conducting Multiple Imaging Modes with One Fluorescence Microscope
08:32

Conducting Multiple Imaging Modes with One Fluorescence Microscope

Published on: October 28, 2018

9.4K

Related Experiment Videos

Last Updated: May 5, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
13:49

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 12, 2011

36.2K
Visualization of Endosome Dynamics in Living Nerve Terminals with Four-dimensional Fluorescence Imaging
10:51

Visualization of Endosome Dynamics in Living Nerve Terminals with Four-dimensional Fluorescence Imaging

Published on: April 16, 2014

8.5K
Conducting Multiple Imaging Modes with One Fluorescence Microscope
08:32

Conducting Multiple Imaging Modes with One Fluorescence Microscope

Published on: October 28, 2018

9.4K

Area of Science:

  • Gastroenterology
  • Oncology
  • Medical Diagnostics

Background:

  • Gastrointestinal tumours frequently present with poor prognoses due to late-stage diagnosis.
  • Advanced-stage diagnosis limits treatment options and patient outcomes.

Purpose of the Study:

  • To emphasize the critical need for early detection of gastrointestinal cancers.
  • To highlight the importance of advancing intraluminal diagnostic techniques in gastroenterology.

Main Methods:

  • Review of current diagnostic challenges in gastroenterology.
  • Analysis of the impact of early versus late diagnosis on prognosis.

Main Results:

  • Late diagnosis is a primary factor contributing to poor outcomes in gastrointestinal tumour patients.
  • Improved intraluminal diagnostic capabilities are essential for timely detection.

Conclusions:

  • Early detection of gastrointestinal tumours significantly improves prognosis.
  • Further development in intraluminal diagnostic tools is imperative for gastroenterology practice.