Related Experiment Video
Updated: Jul 19, 2026

A Multi-detection Assay for Malaria Transmitting Mosquitoes
Published on: February 28, 2015
Does apolipoprotein E polymorphism influence susceptibility to malaria?
M A Wozniak1, E B Faragher, J A Todd
1Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester, UK.
Apolipoprotein E (APOE) genotype influences infection outcomes. APOE epsilon 2 homozygotes had earlier malaria infections, suggesting it may be an early infection risk factor.
Area of Science:
- Genetics
- Infectious Diseases
- Immunology
Background:
- Infection susceptibility and severity vary significantly among individuals.
- Apolipoprotein E (APOE) genotype influences the outcome of infections with certain viruses.
- APOE protein and malaria protozoa share cell entry mediators, suggesting a potential role for APOE in malaria.
Purpose of the Study:
- To investigate the association between apolipoprotein E (APOE) genotype and the timing of malaria infection in infants.
- To determine if APOE isoforms affect malaria parasite density.
Main Methods:
- Examined the apolipoprotein E (APOE) genotypes of infants diagnosed with malaria.
- Compared the age of infection onset and parasite densities across different APOE genotypes.
Main Results:
- Infants with the APOE epsilon 2 genotype were infected with malaria at a significantly earlier age compared to other genotypes.
- Parasite densities were low across all genotypes and did not show significant differences.
Conclusions:
- The APOE epsilon 2 genotype may represent a risk factor for earlier malaria infection in infants.
- Further research with larger sample sizes is warranted to confirm these findings.
More Related Videos
10:22Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
Related Concept Videos
Principles of Pharmacogenetics: Types of Genetic Variants
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Metabolism: Overview
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Malaria