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Does apolipoprotein E polymorphism influence susceptibility to malaria?

M A Wozniak¹, E B Faragher, J A Todd

¹Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester, UK.

Journal of Medical Genetics

|May 15, 2003

Summary

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Apolipoprotein E (APOE) genotype influences infection outcomes. APOE epsilon 2 homozygotes had earlier malaria infections, suggesting it may be an early infection risk factor.

Area of Science:

Genetics
Infectious Diseases
Immunology

Background:

Infection susceptibility and severity vary significantly among individuals.
Apolipoprotein E (APOE) genotype influences the outcome of infections with certain viruses.
APOE protein and malaria protozoa share cell entry mediators, suggesting a potential role for APOE in malaria.

Purpose of the Study:

To investigate the association between apolipoprotein E (APOE) genotype and the timing of malaria infection in infants.
To determine if APOE isoforms affect malaria parasite density.

Main Methods:

Examined the apolipoprotein E (APOE) genotypes of infants diagnosed with malaria.
Compared the age of infection onset and parasite densities across different APOE genotypes.

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Main Results:

Infants with the APOE epsilon 2 genotype were infected with malaria at a significantly earlier age compared to other genotypes.
Parasite densities were low across all genotypes and did not show significant differences.

Conclusions:

The APOE epsilon 2 genotype may represent a risk factor for earlier malaria infection in infants.
Further research with larger sample sizes is warranted to confirm these findings.