Related Experiment Video
Updated: Sep 26, 2026

Prion Safety Laboratory Swipe Test
Published on: February 14, 2025
[Disinfection of gas-permeable contact lenses against prions]
E Comoy1, C Bonnevalle, A Métais
1Département de Recherche Médicale/Direction des Sciences du Vivant, CEA, Fontenay-aux-Roses Cedex. comoy@dsvidf.cea.fr
Abstract:
Potential iatrogenic transmission from patients incubating Creutzfeldt-Jakob disease, especially variant CJD, is a major public health issue. Because the ocular route is very efficient for contamination with prions, re-use of rigid contact lenses in ophthalmology constitutes a potential problem. We therefore evaluated the anti-prion activity of different protocols available for disinfection of lenses. These treatments decreased the infectivity retained on the surface of experimentally contaminated lenses by a factor of at least 10 million. They thus represent an important factor in protecting against possible prion infection via the ocular route.
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