Related Experiment Video

Updated: Aug 7, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

[Retinal vein occlusion and hyperhomocysteinemia]

J Blondel1, A Glacet-Bernard, N Bayani

  • 1Centre Hospitalier National des Quinze-Vingts, Service II, 28, rue de Charenton, 75012 Paris, France.

Journal Francais D'Ophtalmologie
|May 15, 2003
PubMed

Insights

Elevated homocysteine levels are linked to retinal vein occlusion (RVO), a vascular disease. Further research is needed to confirm if vitamin therapy can prevent or treat RVO.

Area of Science:

  • Ophthalmology
  • Cardiovascular Medicine
  • Clinical Research

Background:

  • Elevated plasma homocysteine is a known risk factor for vascular diseases.
  • Retinal vein occlusion (RVO) is a significant cause of vision loss.

Purpose of the Study:

  • To investigate if hyperhomocysteinemia is a risk factor for RVO.
  • To determine if plasma homocysteine levels are a prognostic factor for RVO outcomes.

Main Methods:

  • Plasma homocysteine levels were measured in 101 RVO patients and 29 controls.
  • Correlations between homocysteine, other risk factors, and RVO clinical outcomes were analyzed.

Main Results:

  • RVO patients exhibited significantly higher mean plasma homocysteine levels than controls (11.9 vs 8.6 mmol/l).
  • Hyperhomocysteinemia was more prevalent in ischemic and bilateral RVO cases, though not statistically significant.
  • No significant relation was found between homocysteine and other vascular risk factors, except hematocrit.

Conclusions:

  • Hyperhomocysteinemia appears to be an independent risk factor for RVO.
  • The study did not establish a link between homocysteine levels and severe RVO prognosis.
  • The efficacy of vitamin therapy for RVO prevention or treatment requires further investigation.
Abstract

More Related Videos

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells06:21

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells

Published on: November 4, 2022

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility07:35

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Published on: April 21, 2022

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...