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Updated: Aug 7, 2026
07:23
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
[Retinal vein occlusion and hyperhomocysteinemia]
J Blondel1, A Glacet-Bernard, N Bayani
1Centre Hospitalier National des Quinze-Vingts, Service II, 28, rue de Charenton, 75012 Paris, France.
Journal Francais D'Ophtalmologie
|May 15, 2003
Summary
Elevated homocysteine levels are linked to retinal vein occlusion (RVO), a vascular disease. Further research is needed to confirm if vitamin therapy can prevent or treat RVO.
Area of Science:
- Ophthalmology
- Cardiovascular Medicine
- Clinical Research
Background:
- Elevated plasma homocysteine is a known risk factor for vascular diseases.
- Retinal vein occlusion (RVO) is a significant cause of vision loss.
Purpose of the Study:
- To investigate if hyperhomocysteinemia is a risk factor for RVO.
- To determine if plasma homocysteine levels are a prognostic factor for RVO outcomes.
Main Methods:
- Plasma homocysteine levels were measured in 101 RVO patients and 29 controls.
- Correlations between homocysteine, other risk factors, and RVO clinical outcomes were analyzed.
Main Results:
- RVO patients exhibited significantly higher mean plasma homocysteine levels than controls (11.9 vs 8.6 mmol/l).
- Hyperhomocysteinemia was more prevalent in ischemic and bilateral RVO cases, though not statistically significant.
- No significant relation was found between homocysteine and other vascular risk factors, except hematocrit.
Conclusions:
- Hyperhomocysteinemia appears to be an independent risk factor for RVO.
- The study did not establish a link between homocysteine levels and severe RVO prognosis.
- The efficacy of vitamin therapy for RVO prevention or treatment requires further investigation.
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