Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[SERMs and uterus].

Philippe Touraine1

  • 1Département d'Endocrinologie et Médecine de la Reproduction, Hôpital Necker, 149, rue de Sèvres, 75743 Paris Cedex 15. philippe.touraine@nck.ap-hop-paris.fr

Annales De Medecine Interne
|May 15, 2003
PubMed
Summary

Selective Estrogen Receptor Modulators (SERMs) offer targeted estrogenic and anti-estrogenic effects. These compounds, like raloxifene, benefit bone health while managing uterine and breast tissues, driving new therapeutic developments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Metabolic Risk in Childhood Brain Cancer Survivors with Childhood-Onset Growth Hormone Deficiency.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same author

MSH4 and MSH5 variants in premature ovarian insufficiency: A literature review and case study.

Maturitas·2026
Same author

The polystyrene beads sign: a simple MRI marker for the preoperative diagnosis of papillary hypothalamic craniopharyngiomas.

European journal of endocrinology·2026
Same author

European Society for Paediatric Endocrinology and European Society of Endocrinology Joint Clinical Practice Guidance for Healthcare Transition from Paediatric to Adult Endocrine Care.

Hormone research in paediatrics·2026
Same author

European Society for Paediatric Endocrinology (ESPE) and European Society of Endocrinology (ESE) joint clinical practice guidance for healthcare transition from paediatric to adult endocrine care.

European journal of endocrinology·2026
Same author

RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency†.

Biology of reproduction·2026

Area of Science:

  • Reproductive endocrinology and pharmacology.
  • Molecular mechanisms of hormone action.
  • Development of novel therapeutic agents.

Context:

  • The uterus responds to ovarian steroids, with estrogen promoting endometrial proliferation and progesterone exerting an anti-estrogenic effect.
  • Tamoxifen, initially developed for breast cancer, demonstrated complex tissue-specific estrogenic/anti-estrogenic actions, including uterine effects.
  • The development of Selective Estrogen Receptor Modulators (SERMs) emerged from the need for compounds with targeted hormonal modulation.

Purpose:

  • To explore the development and tissue-specific actions of SERMs.
  • To understand the dual agonistic and antagonistic effects of SERMs on different tissues.
  • To advance therapeutic strategies for conditions influenced by estrogen signaling.

Summary:

  • Estrogen and progesterone exert distinct effects on the uterus, influencing endometrial proliferation and secretory activity.
  • Selective Estrogen Receptor Modulators (SERMs) are non-steroidal compounds designed to selectively modulate estrogen receptor activity.
  • Raloxifene, an early SERM, exhibits beneficial estrogenic effects on bone and anti-estrogenic effects on uterine and breast tissues.

Impact:

  • SERMs offer a promising avenue for targeted therapies in women's health, addressing conditions like osteoporosis and potentially uterine diseases.
  • Understanding SERM pharmacology allows for the design of next-generation compounds with precisely controlled tissue-specific actions.
  • Continued research into SERMs aims to optimize their therapeutic benefits while minimizing adverse effects across various tissues.

Related Experiment Videos