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[Spasticity and botulinum toxin in 2003. An update]
1Service de Neurologie, Hôpital Léopold-Bellan, Paris. Afeve@aol.com
Neuro-Chirurgie
|May 15, 2003
Summary
Botulinum toxin injections effectively treat spasticity in conditions like cerebral palsy and post-stroke upper limb spasticity. This treatment improves range of motion, function, and quality of life across various etiologies.
Area of Science:
- Neurology
- Rehabilitation Medicine
Context:
- Spasticity, a condition characterized by increased muscle tone, affects individuals with various neurological disorders.
- Botulinum toxin injections have emerged as a significant therapeutic option for managing spasticity.
- Previous research has explored botulinum toxin's efficacy in conditions such as cerebral palsy and post-stroke spasticity.
Purpose:
- To review the current indications and efficacy of botulinum toxin injections for managing spasticity across different etiologies.
- To compare the cost-effectiveness of botulinum toxin therapy with other antispastic treatments.
Summary:
- Botulinum toxin injections are increasingly indicated for spasticity beyond cerebral palsy, showing efficacy in post-stroke upper limb spasticity through double-blind, placebo-controlled studies.
- Studies indicate benefits in multiple sclerosis (improved comfort and angulation) and spinal cord injuries (improved gait and sphincter disorders).
- Post-stroke lower limb spasticity shows improved angulation, though gait evaluation remains challenging. Upper limb spasticity demonstrates improvements in angulation, function, and quality of life.
Impact:
- Botulinum toxin offers a valuable treatment modality for improving function and quality of life in patients with diverse spasticity-related conditions.
- The review facilitates informed clinical decision-making by comparing botulinum toxin's efficacy and cost against alternative antispastic therapies.