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[Intracerebral granulocytic sarcoma. A case report]
M El Khorassani1, F Benbrahim, L Hessissen
1Unité d'Hématologie et d'Oncologie Pédiatrique, CHU Ibn Sina, Hôpital d'Enfants, Rabat, Maroc. elkhorassani@wanadoo.net.ma
Neuro-Chirurgie
|May 15, 2003
Summary
Granulocytic sarcoma, a rare brain tumor in children with acute myeloblastic leukemia, can be diagnosed using cerebrospinal fluid and bone marrow studies, avoiding invasive biopsies.
Area of Science:
- Hematology
- Pediatric Oncology
- Neurology
Background:
- Granulocytic sarcoma is a myeloid tumor typically affecting the orbit.
- Brain localization of granulocytic sarcoma is uncommon.
- Acute myeloblastic leukemia (AML) requires careful monitoring for extramedullary relapse.
Observation:
- A case of an 11-year-old boy with AML experiencing relapse with granulocytic sarcoma.
- Symptoms included headache and facial palsy, with CT revealing frontal and occipital masses.
- Cerebrospinal fluid (CSF) analysis showed blastic cells, and bone marrow study confirmed medullary relapse.
Findings:
- The patient achieved medullary and cerebro-meningeal remission after chemotherapy and radiotherapy.
- Cerebrospinal fluid and bone marrow studies were crucial in diagnosing the relapse.
- Non-invasive diagnostic methods can potentially obviate the need for stereotactic biopsy.
Implications:
- Highlights the importance of vigilant monitoring for extramedullary disease in pediatric AML survivors.
- Demonstrates the utility of CSF and bone marrow analysis in diagnosing CNS granulocytic sarcoma.
- Suggests a diagnostic pathway that minimizes invasive procedures for suspected CNS relapse.