Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignancy-associated changes in lactiferous duct epithelium.

Neil Anderson1, J Houghton, S J Kirk

  • 1Department of Pathology, Royal Victoria Hospital, Belfast, U.K. n.anderson@queens-belfast.ac.uk

Analytical and Quantitative Cytology and Histology
|May 16, 2003
PubMed
Summary

Histologically normal breast duct cells from women with lesions show nuclear chromatin changes, indicating the presence of distant breast lesions. This finding may enable minimally invasive breast lesion screening.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventing premature deaths through polygenic risk scores.

Nature communications·2026
Same author

Association of structured continuum emission with dynamic aurora.

Nature communications·2024
Same author

The karyometric signature is altered in fallopian tubes with serous tubal intraepithelial carcinoma.

Gynecologic oncology·2024
Same author

Patient and carer experiences of living with multiple myeloma and myelodysplastic syndrome.

Psycho-oncology·2023
Same author

Concurrent Chemotherapy and Pelvic Radiation Therapy Compared With Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023
Same author

Reports of Injection Site Necrosis After 23-Valent Pneumococcal Vaccine Use.

JAMA internal medicine·2023

Area of Science:

  • Oncology
  • Pathology
  • Biomedical Engineering

Background:

  • Breast lesions require accurate detection methods.
  • Early detection of breast lesions improves patient outcomes.
  • Investigating cellular changes in normal-appearing tissue is crucial for understanding lesion development.

Purpose of the Study:

  • To investigate if histologically normal lactiferous duct epithelium cells from women with breast lesions exhibit detectable changes.
  • To determine if these cellular changes can serve as indicators for the presence of remote ductal lesions.

Main Methods:

  • Tissue sections of lactiferous duct epithelium were prepared from 20 women with breast lesions and 20 controls.
  • Hematoxylin and eosin staining was used.
  • 100 nuclei per case were measured, and nuclear deviation from normal was computed using discriminant functions and multivariate significance tests.

Related Experiment Videos

Main Results:

  • Nuclei in normal-appearing lactiferous duct epithelium from women with lesions showed altered nuclear chromatin distribution patterns.
  • These chromatin changes were statistically significant and evident in all 20 subjects with lesions.
  • Such changes were absent in 19 of 20 control subjects without lesions.

Conclusions:

  • Alterations in nuclear chromatin within histologically normal ductal epithelium can indicate the presence of distant breast lesions.
  • These findings support the potential for developing minimally invasive screening procedures, such as ductal lavage, for breast lesions.