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Membrane-assisted extractive bioconversions.

Pedro Fernandes1, Duarte M F Prazeres, Joaquim M S Cabral

  • 1Center for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais,1049-001 Lisboa, Portugal.

Advances in Biochemical Engineering/Biotechnology
|May 16, 2003
PubMed
Summary
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Membrane reactors integrate bioconversion and in situ product recovery. They enhance biocatalyst protection and process efficiency in extractive bioconversions.

Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Process Integration

Background:

  • Extractive bioconversions often face challenges with product inhibition and separation efficiency.
  • Membrane reactors offer a solution by integrating reaction and separation processes.
  • In situ product recovery (ISPR) is crucial for improving bioconversion yields.

Purpose of the Study:

  • To summarize the application of membrane reactors in extractive bioconversions for ISPR.
  • To analyze various membrane reactor configurations and their influencing factors.
  • To discuss modeling, solvent toxicity, and future trends in this field.

Main Methods:

  • Analysis of different membrane reactor configurations (e.g., biocatalyst location, membrane type).
  • Consideration of enzyme and whole-cell bioconversions.

Related Experiment Videos

  • Modeling of liquid-liquid extractive membrane bioreactor operation (kinetics, mass transfer).

    • Main Results:

    • Membrane reactors enable efficient in situ product recovery, enhancing bioconversion performance.
    • Membrane properties and solvent choice significantly impact biocatalyst activity and protection.
    • Successful examples from literature and authors' labs demonstrate the feasibility of this approach.

    Conclusions:

    • Membrane reactors are effective process integration systems for extractive bioconversions.
    • Careful selection of membrane and solvent is key to overcoming product toxicity and maintaining biocatalyst function.
    • This technology holds significant promise for optimizing bioprocesses.