Related Experiment Video
Updated: Sep 26, 2026

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
Published on: March 1, 2022
Does complexity belie a simple decision--on the Efroni and Cohen critique of the minimal model for a self-nonself
1Conceptual Immunology Group, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. cohn@salk.edu
Abstract:
The immune system somatically generates a large and random paratopic repertoire that must be sorted into those specificities (anti-self) which, if expressed, would debilitate the host and those specificities (anti-nonself) which, if not expressed, would leave the host unprotected from infection. The critique of Efroni and Cohen that minimal models are misleading and without heuristic value is evaluated by illustrative examples.
Related Concept Videos
Stereotype Content Model
Causes of Similarity-Dissimilarity Effect
Self-Discrepancy Theory
Self-Serving Bias
Self-Discrepancy and Its Effects
Fundamental Attribution Error
