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Related Experiment Videos

The Kluyver effect revisited.

Hiroshi Fukuhara1

  • 1Institut Curie, Section de Recherche, Centre Universitaire, Batiment 110, 91405, Orsay, France.

FEMS Yeast Research
|May 16, 2003
PubMed
Summary

The Kluyver effect describes yeast

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Area of Science:

  • Microbiology
  • Biochemistry
  • Yeast Physiology

Background:

  • The Kluyver effect is observed in yeast species where growth on certain sugars, particularly oligosaccharides, is dependent on aerobic conditions and respiration, not fermentation.
  • This phenomenon, termed 'respiration-dependent' growth, means fermentation is blocked under specific conditions, leading to unclear physiological and molecular bases.
  • Yeast can exhibit the Kluyver effect for some sugars but not others, adding complexity to its understanding.

Purpose of the Study:

  • To investigate the extent to which the sugar transporter theory can explain the Kluyver effect across different yeast species and sugars.
  • To explore the molecular basis of respiration-dependent sugar utilization in yeasts.
  • To generalize the findings regarding the role of sugar transporter activity in the Kluyver effect.

Main Methods:

  • Examined the sugar transporter theory of the Kluyver effect.
  • Investigated the relationship between sugar transporter activity and fermentative growth.
  • Assessed the conditions under which sugar uptake is sufficient for fermentative growth versus respiration.

Main Results:

  • Recent findings suggest that low sugar transporter activity may be the cause of the Kluyver effect, hindering fermentative growth.
  • High substrate flow is necessary for fermentative growth, while energy-efficient respiratory growth has lower uptake requirements.
  • The study aimed to generalize these findings to understand the broader applicability of the sugar transporter theory.

Conclusions:

  • The sugar transporter theory provides a potential molecular explanation for the Kluyver effect.
  • Differences in sugar transporter activity levels appear critical in determining respiration-dependent sugar utilization.
  • Further research is needed to fully generalize the sugar transporter theory across diverse yeast species and substrates.

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