Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in

Ronald G Gregg1, Gregory B Willer, James M Fadool

  • 1Department of Biochemistry and Molecular Biology, University of Louisville, 319 Abraham Flexner Way, KY 40202, USA.

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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...