Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Acute coronary thrombosis].

Alain Tedgui1, Ziad Mallat

  • 1INSERM U 541 Hôpital Lariboisière 75475 Paris. ziad.mallat@larib.inserm.fr

La Revue Du Praticien
|May 17, 2003
PubMed
Summary

Atherosclerosis involves arterial wall inflammation. Inflammatory and apoptotic processes destabilize plaques, leading to thrombus formation and ischemic events.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of advanced cardiovascular imaging in rheumatic immune-mediated inflammatory diseases.

Rheumatology (Oxford, England)·2026
Same author

EACVI survey on the use of multi-modality cardiovascular imaging in immune-mediated inflammatory diseases.

European heart journal. Imaging methods and practice·2026
Same author

[Low-dose interleukin-2: A potential immunotherapy for post-myocardial infarction patients].

Medecine sciences : M/S·2026
Same author

Plasma soluble TREM-1 and risk of cardiovascular disease in the population. Results from the Paris Prospective Study III and the CoLaus|PsyCoLaus.

European journal of preventive cardiology·2026
Same author

NK cells promote cardiac cell death and regulate myelopoiesis in myocardial infarction.

Nature communications·2026
Same author

Molecular contrast agents for post-infarct cardiac remodelling: a contemporary review.

European heart journal. Imaging methods and practice·2026

Area of Science:

  • Cardiovascular Biology
  • Inflammation Research
  • Pathology

Context:

  • Atherosclerosis is a chronic inflammatory arterial disease.
  • Ischemic events stem from thrombus formation on unstable atherosclerotic plaques.
  • Plaque instability is linked to inflammatory and apoptotic processes.

Purpose:

  • To elucidate the roles of inflammation and apoptosis in atherosclerotic plaque instability.
  • To understand the mechanisms driving fibrous cap rupture and plaque thrombogenicity.

Summary:

  • Inflammatory mediators contribute to smooth muscle cell loss and collagen degradation, causing fibrous cap rupture.
  • Apoptosis is a key determinant of plaque thrombogenicity.
  • Plaque erosion (40%) and rupture (60%) lead to thrombus formation.

Impact:

  • Highlights the critical involvement of inflammatory and apoptotic pathways in atherothrombosis.
  • Provides insights into mechanisms underlying plaque destabilization and ischemic complications.
  • Informs potential therapeutic strategies targeting inflammation and apoptosis in atherosclerosis.

Related Experiment Videos