Narcolepsy-like symptoms in a patient with down syndrome and without obstructive sleep apnea
Luis Dominguez-Ortega1, Rafael J Salin-Pascual, Elena Díaz-Gállego
1Serv. Medicina Interna, Unidad de Sueño, Hospital 12 de Octubre, Madrid, Spain. luis.dominguez@clinicaludor.com
Objective:
The study reports on a 33-year-old Caucasian female with Down syndrome and narcolepsy-like symptoms.
Method:
After medical and genetic screening, docturnal polysomnography followed by a Multiple Sleep Latency Test and HLA typing were performed. The patient was medication free and reported a number of cataplexy attacks everyday. Each time that she came to the sleep disorders clinic, she was observed to have cataplexy. She also felt extremely drowsy. A mean sleep latency of 8.8 minutes with 4 sleep-onset rapid eye movement periods in the Multiple Sleep Latency Test, with no other sleep disorder that accounts for the symptoms, was obtained. The patient was DQB1*0301, DQB1*0602, as revealed by the last high-resolution serologic typing.
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