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Related Experiment Videos

Limitations of compounding diazepam suspensions from tablets.

D W Newton, S G Schulman, C H Becker

    American Journal of Hospital Pharmacy
    |May 1, 1976
    PubMed
    Summary

    Two diazepam suspensions were tested for drug concentration over 14 days. One suspension maintained acceptable diazepam levels, while the other showed subpotent and inconsistent results.

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    Area of Science:

    • Pharmaceutical Sciences
    • Drug Formulation
    • Pharmacokinetics

    Background:

    • Diazepam is a commonly prescribed medication.
    • Accurate drug dosing in suspensions is critical for patient safety and therapeutic efficacy.
    • Variability in suspension formulation can impact drug concentration and stability.

    Purpose of the Study:

    • To evaluate the diazepam concentration in two different suspension vehicles over a 14-day period.
    • To compare the stability and consistency of diazepam in various liquid formulations.
    • To identify formulation characteristics that ensure acceptable drug concentrations.

    Main Methods:

    • Two types of diazepam suspensions (1 mg/ml) were prepared from 10-mg tablets.
    • Suspensions were stored in amber glass bottles at room temperature for 14 days.
    • Diazepam concentration was measured in each suspension over the study period.

    Main Results:

    • One suspension, containing ethanol, propylene glycol, Syrup USP, and chocolate syrup, maintained 90% diazepam dissolution and acceptable concentrations.
    • The second suspension, using only triturated tablets and Syrup USP, showed only 25% diazepam dissolution with subpotent and inconsistent concentrations.
    • The observed variations in diazepam concentration were independent of the drug's chemical stability.

    Conclusions:

    • Formulation composition significantly impacts diazepam concentration and consistency in oral suspensions.
    • The inclusion of specific excipients like ethanol, propylene glycol, and chocolate syrup can enhance diazepam dissolution and stability.
    • Careful selection of suspension vehicles is crucial for ensuring therapeutic efficacy and patient safety with diazepam formulations.

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