Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contrast superharmonic imaging: a feasibility study.

Ayache Bouakaz1, Boudewijn J Krenning, Wim B Vletter

  • 1Experimental EchocardiographyErasmus MC, Thoraxcenter, Rotterdam, The Netherlands a.bouakaz@erasmusmc.nl

Ultrasound in Medicine & Biology
|May 17, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Focused acoustic vortex-mediated targeted aggregation of engineered bacteria for in situ antibody production to enhance immunotherapy.

Acta biomaterialia·2026
Same author

Therapeutic efficacy of in-vivo IL-12 plasmid delivery using microbubble-assisted ultrasound in a B16F10 mouse melanoma model: a proof of concept.

International journal of pharmaceutics·2025
Same author

Focused ultrasound-triggered escitalopram delivery using microbubble-liposome complexes for rapid and sustained serotonin regulation in depression therapy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Metabolomic profile of cerebral tissue after acoustically-mediated blood-brain barrier opening in a healthy rat model: a focus on the contralateral side.

Frontiers in molecular neuroscience·2024
Same author

Microbubble Enhanced Echocardiography in Current Cardiology Practice.

Reviews in cardiovascular medicine·2024
Same author

Enhancing Curcumin's therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery.

Scientific reports·2024

Superharmonic (SH) imaging enhances contrast-to-tissue ratio (CTR) for improved myocardial perfusion assessment. This novel technique accurately differentiates tissue from contrast agents, showing high sensitivity and specificity in clinical studies.

Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Cardiology

Background:

  • Harmonic imaging improves ultrasound quality using scattered second harmonic components from contrast bubbles.
  • Contrast-to-tissue ratio (CTR) can be limited by tissue contamination, hindering accurate differentiation.
  • Previous research indicated CTR increases with harmonic number order.

Purpose of the Study:

  • To evaluate the clinical feasibility and utility of superharmonic (SH) imaging.
  • To assess SH imaging for myocardial perfusion quantification using SonoVue(R) contrast agent.
  • To determine SH imaging's effectiveness in differentiating perfusion levels.

Main Methods:

  • Developed a superharmonic (SH) contrast imaging method detecting higher harmonics.

Related Experiment Videos

  • Assessed 10 patients with cardiac diseases using SH imaging in triggered mode.
  • Utilized a new 0.8 MHz probe with a mechanical index of 0.2 for SH acquisition.
  • Analyzed myocardial perfusion visually and quantitatively using radiofrequency (RF) processing.

    • Main Results:

    • SH imaging showed no signal from tissue before contrast injection.
    • Myocardial opacification was clearly visualized by SH after SonoVue(R) administration.
    • Measured an echo increase of over 15 dB for myocardial bubbles compared to tissue.
    • Successfully visualized myocardial perfusion post-septal ablation in hypertrophic cardiomyopathy patients.

    Conclusions:

    • Superharmonic (SH) imaging demonstrates high sensitivity and specificity for myocardial perfusion assessment.
    • The technique effectively differentiates between normal and low perfusion areas.
    • SH imaging offers improved contrast visualization and tissue suppression, enhancing diagnostic accuracy.