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Updated: Feb 10, 2026

Isolation of Epithelial Cells from Human Dental Follicle
Published on: November 5, 2021
[Protocol for adapting treatment with vitamin K antagonists before dental extraction]
F Garcia-Darennes1, J Darennes, M Freidel
1Service de Stomatologie de l'Hôpital Cardiovasculaire et Pneumologique Louis Pradel, 28, rue du Doyen Lépine, 69500 Bron.
Background:
The purpose of this study was to validate a protocol for dental extraction in patients taking vitamin K antagonists without changing the treatment when the INR is lower than 2.8.
Material And Methods:
One hundred four extractions (96 patients) were performed during a 9 month period in patients taking vitamin K antagonists. Extraction was performed when the international normalized ratio (INR) was less than 2.8, otherwise, the treatment was modified until the desired INR was reached. Extractions were performed under para-apical and alveolar local anesthesia and sutured with hemostatic gauze.
Results:
Three patients developed postoperative bleeding requiring alveolar revision with local application of tranexamic acid and in one case use of a biological glue.
Discussion:
The following protocol can be proposed: ambulatory extraction under local anesthesia with an INR the day before extraction: the extraction is performed if the INR is<=2.8 using hemostatic gauze suture and tranexamic acid in case of persistent bleeding.
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