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[Fosfomycin].

M Gobernado1

  • 1Servicio de Microbiología, Hospital La Fe, Avda. Campanar 21, 46009 Valencia, Spain.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|May 17, 2003
PubMed
Summary
This summary is machine-generated.

Fosfomycin is a broad-spectrum antibiotic effective against resistant bacteria like MRSA and VRE. It offers synergistic effects, good tissue penetration, and minimal impact on gut flora, making it valuable for various infections.

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Area of Science:

  • Pharmacology
  • Microbiology
  • Infectious Diseases

Context:

  • Fosfomycin is a natural antibiotic with a unique epoxide structure.
  • It targets the initial stage of bacterial cell wall peptidoglycan synthesis.
  • It exhibits broad-spectrum activity, including against challenging pathogens like methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate/resistant Enterococci (VRE).

Purpose:

  • To review the properties, efficacy, and clinical applications of fosfomycin.
  • To highlight its sustained activity and stable resistance profile over time.
  • To discuss its synergistic potential with other antimicrobial agents.

Summary:

  • Fosfomycin demonstrates rapid bactericidal effects and maintains efficacy against resistant strains.

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  • It possesses favorable pharmacokinetic properties, including oral and parenteral administration, good tissue distribution, and renal excretion of the active form.
  • Clinical applications span urinary, respiratory, and severe hospital-acquired infections, with high success rates and minimal side effects, including preservation of normal human flora.

    • Impact:

    • Fosfomycin's efficacy against multidrug-resistant organisms makes it a crucial therapeutic option.
    • Its synergistic potential and favorable safety profile support its use in combination therapies and in specific patient populations.
    • Additional benefits include immunomodulatory effects and protection against nephrotoxicity from other drugs.