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Syphilitic cervical lymphadenopathy.

J Sato1, H Tsubota, T Himi

  • 1Department of Otolaryngology, Sapporo Medical University, School of Medicine, S-1W-16 Chuo-ku, Sapporo 060-8543, Japan. jsato@sapmed.ac.jp

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|May 17, 2003
PubMed
Summary

Syphilis, a great mimic, can cause cervical lymphadenopathy. This case highlights the importance of considering syphilis in the differential diagnosis of neck lymph node swelling, even without typical lesions.

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Area of Science:

  • Infectious Diseases
  • Otolaryngology
  • Dermatology

Background:

  • Syphilis is a complex systemic infection known for its diverse clinical presentations.
  • Cervical lymphadenopathy is a common clinical finding with a broad differential diagnosis.
  • Traditionally, syphilis is not widely recognized as a primary cause of isolated cervical lymphadenopathy.

Observation:

  • A 21-year-old male presented with significant unilateral cervical lymphadenopathy.
  • The patient lacked typical syphilitic markers such as oropharyngeal chancres or genital/skin lesions.
  • Imaging studies, including CT and MR, revealed extensive cervical lymphadenopathy.

Findings:

  • Serologic tests for syphilis were positive in the patient.
  • The clinical presentation and diagnostic findings strongly implicated syphilis.

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  • This case demonstrates a less common manifestation of secondary syphilis.

    • Implications:

    • Clinicians should consider syphilis in the differential diagnosis of cervical lymphadenopathy, particularly in young adults.
    • The "great mimicry" of syphilis extends to presentations without classic mucocutaneous signs.
    • Early recognition and treatment of syphilitic cervical lymphadenopathy are crucial to prevent complications.