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Related Experiment Videos

Aging and outcome in schizophrenia.

D V Jeste1, E W Twamley, L T Eyler Zorrilla

  • 1Department of Psychiatry, University of California, San Diego, CA, USA. djeste@ucsd.edu

Acta Psychiatrica Scandinavica
|May 20, 2003
PubMed
Summary

Aging schizophrenia patients show stable, not deteriorating, psychopathology. Elderly patients remain impaired compared to controls, disputing notions of significant improvement or decline.

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Area of Science:

  • Geriatric Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Long-term outcomes in schizophrenia are debated.
  • Few studies compare elderly schizophrenia outpatients to healthy controls.

Purpose of the Study:

  • Examine age-related changes in schizophrenia outpatients.
  • Compare clinical features, psychopathology, and functioning in elderly patients versus controls.
  • Characterize outcomes in aging schizophrenia patients.

Main Methods:

  • Comprehensive assessments of 290 outpatients and 144 comparison subjects (aged 40-85).
  • Evaluated clinical features, psychopathology, movement abnormalities, well-being, and daily functioning.

Main Results:

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  • Aging correlated with reduced psychopathology in patients, independent of illness duration.
  • No accelerated aging-related decline observed in patients.
  • Elderly patients exhibited greater impairment than comparison subjects across various measures.

    • Conclusions:

    • Schizophrenia's course in late life appears stable.
    • Most elderly patients with schizophrenia remain symptomatic and functionally impaired.
    • Findings challenge theories of progressive deterioration or marked improvement in aging schizophrenia patients.