Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Severe drug rashes in three siblings simultaneously.

L Johnson-Reagan1, S L Bahna

  • 1Allergy/Immunology Section, Department of Pediatrics, Louisiana State, University Health Sciences Center, Shreveport, Louisiana 71130, USA.

Allergy
|May 20, 2003
PubMed
Summary

Three siblings experienced severe skin reactions, erythema multiforme and Stevens-Johnson syndrome, after taking thiabendazole, suggesting a genetic link to adverse drug reactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gluten sensitivities and the allergist: Threshing the grain from the husks.

Allergy·2017
Same author

Acute cardiac disease in a patient with hyper-IgE syndrome.

European annals of allergy and clinical immunology·2017
Same author

Hypersensitivities to sesame and other common edible seeds.

Allergy·2016
Same author

Pathogenesis of milk hypersensitivity.

Immunology today·2014
Same author

Milk-induced wheezing in children with asthma.

Allergologia et immunopathologia·2012
Same author

C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks--final results of the I.M.P.A.C.T.2 study.

Allergy·2011

Area of Science:

  • Pharmacogenomics
  • Dermatology
  • Immunology

Background:

  • Adverse drug reactions (ADRs) are typically sporadic.
  • Genetic factors influencing susceptibility to multiple ADRs remain unclear.
  • This study investigates a rare familial occurrence of severe cutaneous drug reactions.

Observation:

  • Three siblings simultaneously developed severe rashes within weeks of thiabendazole administration.
  • The rashes presented as erythema multiforme and Stevens-Johnson syndrome.
  • No specific pattern was observed in serum immunoglobulin levels during follow-up, aside from initial elevations.

Findings:

  • Simultaneous severe cutaneous drug reactions (SCDRs) in siblings suggest a shared genetic susceptibility.
  • Thiabendazole was identified as the causative agent for the observed SCDR.

Related Experiment Videos

  • Immunoglobulin levels showed transient, non-specific elevations (IgG, IgA, IgM).

    • Implications:

    • The findings support the hypothesis of a genetic predisposition to specific adverse drug reactions.
    • This case highlights the importance of considering familial history in evaluating SCDR.
    • Further research into genetic markers for thiabendazole hypersensitivity is warranted.