Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory deficits and retrieval processes in ALS.

M C Mantovan1, L Baggio, G Dalla Barba

  • 1Department of Neurological and Psychiatric Sciences, University of Padua, Padua, Italy. mcmantovan@libero.it

European Journal of Neurology
|May 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysferlinopathy course and sportive activity: clues for possible treatment.

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology·2011
Same author

Observational clinical study in juvenile-adult glycogenosis type 2 patients undergoing enzyme replacement therapy for up to 4 years.

Journal of neurology·2011
Same author

Allelic and phenotypic heterogeneity in 49 Italian patients with the muscle form of CPT-II deficiency.

Clinical genetics·2011
Same author

Aberrant splicing and expression of the non muscle myosin heavy-chain gene MYH14 in DM1 muscle tissues.

Neurobiology of disease·2011
Same author

Observation of the decay B- → D(s)((*)+) K- ℓ- ν(ℓ).

Physical review letters·2011
Same author

Search for production of invisible final states in single-photon decays of Υ(1S).

Physical review letters·2011
Same journal

Diagnostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in Differentiating Primary From Serious Secondary Headache.

European journal of neurology·2026
Same journal

Neuropsychiatric Adverse Events Associated With Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion in Clinical Practice: A Multicenter Study.

European journal of neurology·2026
Same journal

Transfusion-Associated Graft-Versus-Host Disease Risk and Transfusion Requirements After Cladribine in Multiple Sclerosis: Time to Revise Irradiation Policy?

European journal of neurology·2026
Same journal

Blood Pressure Control With Clevidipine Is Associated With Hematoma Volume Reduction in Acute Hypertensive Intracerebral Hemorrhage: A Single-Center Prospective Cohort Study.

European journal of neurology·2026
Same journal

CGRP-Targeted Therapy in Vestibular Migraine-How Strong Is the Evidence?

European journal of neurology·2026
Same journal

Direct Thrombectomy vs. Combined Treatment With Intravenous Thrombolysis in the Extended Time Window: A Target Trial Emulation.

European journal of neurology·2026
See all related articles

Amyotrophic lateral sclerosis (ALS) patients exhibit long-term memory deficits, particularly in recalling early information. This impairment, linked to frontal lobe dysfunction, does not improve with memory cues, unlike in healthy individuals.

Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Subtle neuropsychological deficits, including memory impairment, are observed in amyotrophic lateral sclerosis (ALS) patients without dementia.
  • The precise origin of memory deficits in ALS remains undefined.

Purpose of the Study:

  • To investigate the nature of memory impairment in ALS patients.
  • To explore the relationship between memory deficits, frontal lobe function, and cerebral blood perfusion in ALS.

Main Methods:

  • Neuropsychological screening of 20 ALS patients and normal controls.
  • Assessment of semantic encoding and post-encoding cue effects on word list retrieval.
  • Correlation of memory impairment severity with cerebral blood perfusion using single-photon emission computed tomography (SPECT).

Related Experiment Videos

Main Results:

  • ALS patients showed moderate deficits in frontal and memory tests, with normal short-term memory.
  • A long-term memory deficit was indicated by a poor primacy effect in serial position retrieval.
  • SPECT revealed hypoperfusion in frontal and temporal areas of ALS patients.
  • ALS patients' long-term memory deficit did not improve with post-encoding cues, unlike in controls.

Conclusions:

  • ALS patients exhibit a specific long-term memory deficit, characterized by difficulties in recalling early presented information.
  • This deficit is hypothesized to stem from abnormal retrieval processes associated with frontal lobe dysfunction.
  • Frontal lobe dysfunction in ALS may impair the generation of stable long-term memory traces during encoding.