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Published on: May 6, 2013
Type 2 diabetes presenting as diabetic ketoacidosis in adolescence
1Department of Endocrinology and Metabolic Medicine, St Mary's Hospital, London, UK. j.valabhji@ic.ac.uk
Abstract:
We report two black adolescent subjects who presented with diabetic ketoacidosis, but who lacked autoimmune markers and demonstrated clinical and biochemical characteristics more typical of Type 2 diabetes, including obesity, acanthosis nigricans, positive family history for Type 2 diabetes, and Type 2 diabetic dyslipidaemia. Subsequent to acute presentation, insulin was discontinued in both subjects and excellent glycaemic control was achieved with metformin therapy alone. Four months following acute presentation, both had adequate C-peptide responses to intravenous glucagon. Type 2 diabetes can present as diabetic ketoacidosis in obese adolescent subjects.
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