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APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men
L Baum1, B Tomlinson, G N Thomas
1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China. lwbaum@cuhk.edu.hk
Abstract:
A new apolipoprotein gene, APOA5, was recently discovered near the APOA1/C3/A4 gene cluster. Transgenic mice overexpressing the homologous gene, apoa5, showed reduced plasma triglyceride levels, while knockout mice had greatly increased triglycerides, suggesting that human genetic variants affecting expression of the protein product, APOAV, might affect triglyceride levels. Polymorphisms in the APOA5 gene were indeed found to be associated with triglyceride levels in men, though not in women. We sought to confirm the association of the APOA5-1131T>C polymorphism with triglyceride levels in 167 Chinese men chosen for having either high (>/=1.7 mm, n = 82) or low (