Related Experiment Video
Updated: Aug 10, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
Published on: February 21, 2016
Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait
M Tadin-Strapps1, J C Salas-Alanis, L Moreno
1Department of Genetics, Dermatology and Pediatrics, Columbia University, New York, NY, USA.
Abstract:
We report a large Mexican kindred with a variant form of congenital universal hypertrichosis that is inherited in an apparent X-linked recessive manner. In addition to the generalized hypertrichosis, the affected individuals have dental malformations and deafness. Males are more severely affected than females who exhibit only mild hypertrichosis, but not deafness or dental anomalies. Haplotype analysis in this pedigree revealed linkage to a 13-cM region on chromosome Xq24-q27.1 between markers GATA198A10 and DXS8106. Localization of the gene underlying this form of hypertrichosis is the initial step in identifying genes on the X chromosome that are involved in the control of hair growth and development.
Related Concept Videos
Genetic Lingo
Pedigree Analysis
Pleiotropy
X-linked Traits
Sex-linked Disorders
X-linked Traits

