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Activation-induced cell death in T cells.
Douglas R Green1, Nathalie Droin, Michael Pinkoski
1La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. doug@liai.org
Immunological Reviews
|May 20, 2003
Summary
Programmed cell death, or apoptosis, is crucial for immune system function. This review explores activation-induced cell death (AICD) in T lymphocytes, a key process for immune tolerance and homeostasis.
Area of Science:
- Immunology
- Cell Biology
Background:
- Programmed cell death is essential for lymphocyte development and immune system regulation.
- Activation-induced cell death (AICD) in T lymphocytes is a critical process following T-cell receptor activation.
Purpose of the Study:
- To review the phenomenon of activation-induced cell death (AICD) in T lymphocytes.
- To discuss the various mechanisms and roles of AICD in immune tolerance and homeostasis.
Main Methods:
- Literature review of T lymphocyte activation and apoptosis.
- Analysis of different mechanisms of AICD, including Fas ligand (FasL) involvement.
Main Results:
- AICD can occur autonomously and is influenced by T-cell activation.
- AICD plays vital roles in central and peripheral deletion for tolerance and homeostasis.
- Fas ligand (FasL) mediates AICD in peripheral T cells but not typically in thymocytes.
Conclusions:
- Different forms of AICD may utilize distinct mechanisms.
- Emerging models suggest nonlymphoid tissue FasL induction as a sensing mechanism for immune infiltration and peripheral deletion.