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Related Experiment Videos

The enteric nervous system I: organisation and classification.

Mark Berner Hansen1

  • 1Department of Gastrointestinal Surgery K, Bispebjerg University Hospital of Copenhagen, Copenhagen NV, Denmark. mbh@dadlnet.dk

Pharmacology & Toxicology
|May 20, 2003
PubMed
Summary

Neurogastroenterology advances our understanding of the enteric nervous system (ENS), a semi-independent neural network in the gut. This review details ENS organization and classification for new gastrointestinal disorder treatments.

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Area of Science:

  • Neurogastroenterology
  • Gastrointestinal Physiology
  • Neuroscience

Background:

  • The enteric nervous system (ENS), a complex neural network within the gastrointestinal tract, plays a crucial role in gut function.
  • Neurogastroenterology is gaining recognition in clinical pharmacology due to the ENS's significance.
  • Understanding the ENS is vital for addressing gastrointestinal disorders.

Observation:

  • The ENS comprises neurones functioning semi-independently from the central nervous system.
  • It regulates critical gut functions including motility, secretions (exocrine and endocrine), microcirculation, and immune responses.
  • This review focuses on the structural organization and classification of the ENS.

Findings:

  • Major advances have been made in comprehending the ENS's structure and function.

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  • The ENS's independent yet interactive nature with the central nervous system is a key characteristic.
  • Classification and organization are fundamental to understanding ENS physiology.

    • Implications:

    • Increased knowledge of ENS physiology, pathophysiology, and pharmacology can lead to novel therapeutic strategies.
    • This foundational understanding is essential for developing new treatments for various gastrointestinal disorders.
    • Part one of this review series lays the groundwork by describing ENS organization and classification.