Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathologic changes in ferrets exposed to pseudorabies virus.

K I Ohshima, J R Gorham, J B Henson

    American Journal of Veterinary Research
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The suppression of Antarctic bottom water formation by melting ice shelves in Prydz Bay.

    Nature communications·2016
    Same author

    Potential regime shift in decreased sea ice production after the Mertz Glacier calving.

    Nature communications·2012
    Same author

    A helpful technic in making acid-fast stains.

    American journal of clinical pathology·2010
    Same author

    First results from the crystal structure analysis beamline at SPring-8.

    Journal of synchrotron radiation·2004
    Same author

    Distribution of tyrosine aminotransferase activity in mink (Mustela vison).

    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology·2001
    Same author

    Pathogenesis of two strains of lion (Panthera leo) morbillivirus in ferrets (Mustela putorius furo).

    Veterinary pathology·2001

    This study reveals how pseudorabies virus infection affects ferrets, detailing lesion development and spread. Findings show the virus impacts the central nervous system via nerve pathways and potentially the bloodstream.

    Area of Science:

    • Veterinary Pathology
    • Virology
    • Infectious Diseases

    Background:

    • Pseudorabies virus (PRV) poses a significant threat to animal health.
    • Understanding PRV pathogenesis in diverse species is crucial for disease control.
    • Ferrets serve as a relevant model for studying PRV infection.

    Purpose of the Study:

    • To investigate the pathological effects of experimental pseudorabies virus infection in ferrets.
    • To determine the relationship between viral dose, inoculation route, and lesion development.
    • To elucidate the dissemination routes of pseudorabies virus within the ferret host.

    Main Methods:

    • Experimental inoculation of ferrets via various routes.
    • Gross and microscopic examination of tissues for lesions.

    Related Experiment Videos

  • Analysis of incubation period and lesion distribution.

    • Main Results:

    • Nonsuppurative meningoencephalomyelitis and visceral lesions were observed.
    • Incubation period correlated with viral dose and proximity to the central nervous system.
    • Lesion distribution in the central nervous system mapped to peripheral nerve pathways.
    • Evidence suggested a role for the lymphohematogenous route in viral dissemination.

    Conclusions:

    • Pseudorabies virus infection in ferrets causes significant neurological and visceral damage.
    • Viral spread is influenced by inoculation site and host-specific nerve pathways.
    • Both neural and lymphohematogenous routes are implicated in PRV dissemination in ferrets.