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Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation
Darrin H Brager1, Xiang Cai, Scott M Thompson
1Department of Physiology, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, Maryland 21201, USA.
Nature Neuroscience
|May 20, 2003
Abstract:
Vesicle exocytosis is mediated by the complex interaction between synaptic vesicle and plasma membrane proteins, many of which are substrates for protein kinases. Exogenous protein kinase activators increase release probability at several mammalian CNS synapses, but the physiological conditions under which presynaptic protein kinases become activated are not known. We report here that calcium/phospholipid-dependent protein kinase C (PKC) is activated by high-frequency stimulation and mediates post-tetanic potentiation (PTP) in the rat hippocampus.