Related Experiment Video
Updated: Sep 26, 2026

Mouse Heterotopic Cervical Cardiac Transplantation Utilizing Vascular Cuffs
Published on: June 23, 2022
[Cardiac transplantation]
Kazuhiro Yamamoto1, Seiji Takashima, Tohru Masuyama
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine.
Insights
Cardiac transplantation is a vital treatment for end-stage heart failure. While established globally, Japan faces challenges in increasing the number of these life-saving procedures despite initial success.
Area of Science:
- Cardiology
- Transplantation Medicine
- Medical Ethics
Context:
- Cardiac transplantation is a recognized treatment for end-stage heart failure in developed nations.
- Japan's first cardiac transplant under new legislation occurred in February 1999.
- Post-legislation, there was initial progress in obtaining consent for brain-dead donor transplants.
Purpose:
- To review the status of cardiac transplantation in Japan following the 1999 legislation.
- To highlight the need for increased cardiac transplantations in Japan.
- To advocate for cardiac transplantation as a standard therapy for heart failure.
Summary:
- The first Japanese cardiac transplant occurred in 1999, with subsequent improvements in consent for brain-dead donors.
- However, the volume of cardiac transplantations in Japan remained insufficient in the following three years.
- This indicates a need for further development and expansion of the program.
Impact:
- Increased cardiac transplant rates could establish it as a mainstream therapy for heart failure in Japan.
- Broader acceptance and implementation of cardiac transplantation can save more lives.
- Further research and policy adjustments may be needed to overcome barriers to transplantation.
Abstract:
Cardiac transplantation has been established as a therapeutic strategy for patients with end-stage heart failure in the developed countries. In Japan, the first cardiac transplantation under the new legislation was successfully performed on February 1999 in Osaka University Hospital. Following this successful operation, the agreement with the transplantation under brain death seems to be further obtained in Japan. However, the number of the transplantation performed during the following 3 years was not enough. Thus, we wish that the number will further increase and that the transplantation will become one of the established therapeutic strategies for end-stage heart failure in our county.
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Kidney Transplant I: Introduction

