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Related Experiment Videos

Host defences to Citrobacter rodentium.

Thomas T MacDonald1, Gad Frankel, Gordon Dougan

  • 1Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK. t.t.macdonald@soton.ac.uk

International Journal of Medical Microbiology : IJMM
|May 21, 2003
PubMed
Summary

Citrobacter rodentium, a mouse colon pathogen, serves as a model for studying gut infections. Its type III secretion system mimics human E. coli, aiding research into host-bacterial interactions and gut inflammation.

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Citrobacter rodentium is a natural bacterial pathogen infecting the mouse distal colon.
  • It employs type III secretion systems (T3SS), similar to human enteropathogenic and enterohemorrhagic Escherichia coli.
  • This T3SS mechanism is crucial for colonizing gut epithelial cells.

Purpose of the Study:

  • To establish Citrobacter rodentium as an ideal model for studying host-bacterial pathogen interactions in vivo.
  • To investigate the relationship between gut inflammation and anti-bacterial immunity.
  • To leverage the similarities between C. rodentium infection and inflammatory bowel disease (IBD) for research.

Main Methods:

  • Utilizing the mouse model to study Citrobacter rodentium infection.

Related Experiment Videos

  • Analyzing the molecular mechanisms of type III secretion.
  • Observing host responses including mucosal inflammation and anti-bacterial immunity.

    • Main Results:

    • Citrobacter rodentium effectively colonizes mouse gut epithelial cells via T3SS.
    • Infection induces mucosal inflammation with characteristics similar to human IBD.
    • The model allows for in vivo investigation of host-pathogen dynamics.

    Conclusions:

    • Citrobacter rodentium is a valuable model for studying gut pathogen colonization and host immune responses.
    • The model facilitates research into the interplay between inflammation and immunity in the gastrointestinal tract.
    • Understanding C. rodentium interactions can inform studies on human enteric infections and IBD.