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Effect of protease-activated receptors on guinea-pig ileum contraction in vitro

B Y C Wan1, A Alic, K H Peh

  • 1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|May 21, 2003
PubMed
Abstract

No abstract available in PubMed .

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GPCRs Regulate Adenylyl Cylase Activity01:09

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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
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