Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum creatine phosphokinase in normal newborns.

N Gilboa, J R Swanson

    Archives of Disease in Childhood
    |April 1, 1976
    PubMed
    Summary

    Serum creatine phosphokinase (CPK) levels are significantly elevated in newborns compared to adults. These levels normalize within weeks, suggesting delayed screening for Duchenne-type muscular dystrophy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Implementation of a multidisciplinary guideline improves preterm infant admission temperatures.

    Journal of perinatology : official journal of the California Perinatal Association·2017
    Same author

    Roadmap to a successful quality improvement project.

    Journal of perinatology : official journal of the California Perinatal Association·2016
    Same author

    Antenatal corticosteroids before 24 weeks: is it time?

    Journal of perinatology : official journal of the California Perinatal Association·2016
    Same author

    The complete blood cell count in a refined cohort of preterm NEC: the importance of gestational age and day of diagnosis when using the CBC to estimate mortality.

    Journal of perinatology : official journal of the California Perinatal Association·2015
    Same author

    Surgical necrotizing enterocolitis defined.

    Journal of perinatology : official journal of the California Perinatal Association·2014
    Same author

    Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.

    Journal of perinatology : official journal of the California Perinatal Association·2014

    Area of Science:

    • Biochemistry
    • Neonatal Medicine
    • Pediatric Neurology

    Background:

    • Serum creatine phosphokinase (CPK) is an enzyme indicator of muscle damage.
    • Elevated CPK levels in newborns can complicate the diagnosis of neuromuscular disorders.

    Purpose of the Study:

    • To establish normal ranges of serum CPK activity in healthy newborns.
    • To determine the typical decline pattern of neonatal CPK levels.
    • To assess the impact of birth trauma on neonatal CPK activity.

    Main Methods:

    • Measured serum CPK activity in 70 normal newborns.
    • Compared neonatal CPK levels to adult and older child reference ranges.
    • Tracked CPK activity changes during the first 6-10 weeks of life.
    • Investigated correlation between birth trauma and CPK levels.

    Main Results:

    • Normal newborns exhibit significantly higher serum CPK activity (up to 10x adult levels).
    • CPK levels decrease to near-normal within 4 days and normalize by 6-10 weeks.
    • No significant correlation found between birth trauma and elevated CPK.
    • Cord blood CPK levels are lower than venous and capillary blood CPK.

    Conclusions:

    • Neonatal hyperCKemia is a normal physiological finding.
    • Routine newborn screening for Duchenne-type muscular dystrophy should be deferred for several weeks post-delivery.
    • Understanding normal CPK kinetics in neonates is crucial for accurate diagnosis of muscular dystrophies.

    Related Experiment Videos