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A randomized controlled study of three targets of propofol plasma concentration in patients undergoing uterine
Ketchada Uerpairojkit1, Pakorn Urusopone, Wanna Somboonviboon
1Department of Anesthesia, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Pratumwan, Bangkok, Thailand. ketchada@hotmail.com
Aim:
To compare the efficacy and the complications of three target levels of propofol plasma concentration in patients undergoing uterine dilation and curettage.
Methods:
Sixty-nine patients were randomly allocated to receive propofol target controlled infusion at different target concentrations of 4 (group I), 5 (group II) and 6 (group III) mcg/mL combined with 1 microg/kg of fentanyl and 66% of nitrous oxide. Patients' movement during the procedure, hemodynamic variables, oxygen saturation, end tidal carbon dioxide, time to sleep and awake, and bispectral index score were recorded.
Results:
Seven patients in group I, one in group II, and none in group III (P < 0.05) moved grossly during the procedure. More patients in group III developed hypotension (5 vs 0 and 2 in group I and II, P < 0.05), but no difference was found regarding respiratory complication. No difference was found in time to sleep, but time to wake was longer in group III.
Conclusion:
Propofol infusion at the target concentration of 5 microg/mL was recommended for uterine dilation and curettage when it was administered with fentanyl 1 microg/kg and nitrous oxide 66% under close monitoring and appropriate respiratory management.
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