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Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization
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An integrated approach to identifying chemically induced posttranslational modifications using comparative MALDI-MS

Maria D Person1, Terrence J Monks, Serrine S Lau

  • 1Center for Molecular and Cellular Toxicology, Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, 78712, USA.

Chemical Research in Toxicology
|May 21, 2003
PubMed
Summary

This study introduces an unbiased proteomics strategy to identify novel posttranslational modifications and chemical adducts. The method uses mass spectrometry (MS) and tandem mass spectrometry (MS/MS) for accurate characterization of protein modifications.

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